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Second, reverse causality cannot be fully excluded: women with obesity, PCOS, or metabolic concerns may consciously increase NNS consumption for weight management, thereby confounding the observed associations with menstrual irregularity or pubertal timing

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Delta sleep-inducing peptide (DSIP), composed of the amino acid sequence WAGGDASGG, has also demonstrated notable analgesic and tissue-regenerative effects, though its primary role was promotion of sleep [189]